/* ========================================
   MEKanistic Therapeutics - Global Styles
   ======================================== */

:root {
    /* MEKanistic Brand Colors - From Official Logo (EXACT) */
    --primary-green: #1EC9A4;
    --primary-blue: #5AB6E5;
    --primary-purple: #B8A0DC;
    --primary-teal: #1EC9A4;
    
    /* Gradient Variations - Three Color Gradient */
    --gradient-primary: linear-gradient(90deg, #1EC9A4 0%, #5AB6E5 50%, #B8A0DC 100%);
    --gradient-hero: linear-gradient(135deg, rgba(30, 201, 164, 0.1) 0%, rgba(184, 160, 220, 0.1) 100%);
    --gradient-overlay: linear-gradient(180deg, rgba(15, 23, 42, 0.9) 0%, rgba(30, 41, 59, 0.95) 100%);
    
    /* Neutral Colors */
    --color-dark: #0F172A;
    --color-dark-alt: #1E293B;
    --color-gray: #475569;
    --color-gray-light: #94A3B8;
    --color-white: #FFFFFF;
    --color-off-white: #F8FAFC;
    
    /* Typography */
    --font-primary: 'Inter', -apple-system, BlinkMacSystemFont, 'Segoe UI', sans-serif;
    --font-heading: 'Space Grotesk', var(--font-primary);
    
    /* Spacing */
    --spacing-xs: 0.5rem;
    --spacing-sm: 1rem;
    --spacing-md: 2rem;
    --spacing-lg: 4rem;
    --spacing-xl: 6rem;
    
    /* Border Radius */
    --radius-sm: 0.5rem;
    --radius-md: 1rem;
    --radius-lg: 1.5rem;
    
    /* Shadows */
    --shadow-sm: 0 1px 3px rgba(0, 0, 0, 0.1);
    --shadow-md: 0 4px 6px rgba(0, 0, 0, 0.1);
    --shadow-lg: 0 10px 25px rgba(0, 0, 0, 0.15);
    --shadow-xl: 0 20px 40px rgba(0, 0, 0, 0.2);
    
    /* Transitions */
    --transition-fast: 0.2s ease;
    --transition-base: 0.3s ease;
    --transition-slow: 0.5s ease;
}

/* ========================================
   Reset & Base Styles
   ======================================== */

* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

html {
    scroll-behavior: smooth;
    font-size: 16px;
}

body {
    font-family: var(--font-primary);
    color: var(--color-dark);
    background-color: var(--color-white);
    line-height: 1.6;
    overflow-x: hidden;
    width: 100%;
    max-width: 100vw;
}

.container {
    max-width: 1200px;
    margin: 0 auto;
    padding: 0 var(--spacing-md);
    width: 100%;
}

img {
    max-width: 100%;
    height: auto;
    display: block;
}

section {
    padding: var(--spacing-xl) 0;
}

/* Typography */
h1, h2, h3, h4, h5, h6 {
    font-family: var(--font-heading);
    font-weight: 700;
    line-height: 1.2;
    color: var(--color-dark);
}

a {
    text-decoration: none;
    color: inherit;
    transition: var(--transition-base);
}

ul {
    list-style: none;
}

img {
    max-width: 100%;
    height: auto;
    display: block;
}

/* ========================================
   Navigation
   ======================================== */

.navbar {
    position: fixed;
    top: 0;
    left: 0;
    right: 0;
    background: rgba(255, 255, 255, 0.95);
    backdrop-filter: blur(10px);
    z-index: 1000;
    box-shadow: var(--shadow-sm);
    transition: var(--transition-base);
}

.navbar.scrolled {
    box-shadow: var(--shadow-md);
}

.nav-wrapper {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: var(--spacing-sm) 0;
}

.logo {
    display: flex;
    align-items: center;
    gap: 0.75rem;
}

.logo-mark {
    height: 40px;
    width: auto;
    max-width: 100%;
    transition: var(--transition-base);
}

.logo-text {
    font-family: var(--font-heading);
    font-size: 1.75rem;
    font-weight: 700;
    color: #000000;
    letter-spacing: -0.01em;
    line-height: 1;
    white-space: nowrap;
}

.nav-menu {
    display: flex;
    gap: 1.2rem;
    align-items: center;
    list-style: none;
    margin: 0;
    padding: 0;
    flex-wrap: nowrap;
}

.nav-menu li {
    display: flex;
    align-items: center;
}

.nav-link {
    font-weight: 500;
    font-size: 0.9rem;
    color: var(--color-dark);
    padding: var(--spacing-xs) 0.65rem;
    border-radius: var(--radius-sm);
    transition: var(--transition-base);
    white-space: nowrap;
    display: inline-flex;
    align-items: center;
    line-height: 1.5;
    text-decoration: none;
}

.nav-link:hover {
    color: var(--primary-teal);
    background: rgba(30, 201, 164, 0.1);
}

.mobile-toggle {
    display: none;
    flex-direction: column;
    gap: 0.25rem;
    background: none;
    border: none;
    cursor: pointer;
    padding: var(--spacing-xs);
}

.mobile-toggle span {
    width: 24px;
    height: 2px;
    background: var(--color-dark);
    transition: var(--transition-base);
}

/* ========================================
   Buttons
   ======================================== */

.btn {
    display: inline-flex;
    align-items: center;
    gap: var(--spacing-xs);
    padding: 0.875rem 1.75rem;
    font-weight: 600;
    border-radius: var(--radius-md);
    transition: var(--transition-base);
    cursor: pointer;
    border: 2px solid transparent;
    font-size: 1rem;
}

.btn-primary {
    background: var(--gradient-primary);
    color: var(--color-white);
    box-shadow: var(--shadow-md);
}

.btn-primary:hover {
    transform: translateY(-2px);
    box-shadow: var(--shadow-lg);
}

.btn-secondary {
    background: var(--color-white);
    color: var(--color-dark);
    border: 2px solid var(--primary-teal);
}

.btn-secondary:hover {
    background: var(--primary-teal);
    color: var(--color-white);
}

.btn-primary-outline {
    background: transparent;
    color: var(--primary-teal);
    border: 2px solid var(--primary-teal);
    padding: 0.5rem 1.25rem;
    display: inline-flex;
    align-items: center;
    justify-content: center;
    line-height: 1.5;
}
}

.btn-primary-outline:hover {
    background: var(--primary-teal);
    color: var(--color-white);
}

/* ========================================
   Hero Section
   ======================================== */

.hero {
    position: relative;
    min-height: 100vh;
    display: flex;
    align-items: center;
    padding-top: 80px;
    overflow: hidden;
    background: linear-gradient(135deg, 
        rgba(30, 201, 164, 0.03) 0%, 
        rgba(90, 182, 229, 0.03) 50%, 
        rgba(184, 160, 220, 0.03) 100%);
}

.hero-background {
    position: absolute;
    inset: 0;
    background: linear-gradient(135deg, 
        rgba(30, 201, 164, 0.05) 0%, 
        rgba(90, 182, 229, 0.05) 50%, 
        rgba(184, 160, 220, 0.05) 100%);
    z-index: -1;
}

.hero-background::before {
    content: '';
    position: absolute;
    inset: 0;
    background: radial-gradient(circle at 30% 50%, 
        rgba(30, 201, 164, 0.08) 0%, 
        transparent 50%);
}

.hero-content {
    max-width: 900px;
    margin: 0 auto;
    text-align: center;
    animation: fadeInUp 1s ease;
}

.hero-badge {
    display: inline-flex;
    align-items: center;
    gap: var(--spacing-xs);
    padding: 0.625rem 1.25rem;
    background: rgba(30, 201, 164, 0.1);
    border: 1px solid var(--primary-teal);
    border-radius: 2rem;
    color: var(--primary-teal);
    font-size: 0.95rem;
    font-weight: 600;
    margin-bottom: 1.5rem;
}

.hero-title {
    font-size: 4rem;
    font-weight: 700;
    margin-bottom: var(--spacing-sm);
    color: #1a1a1a;
    line-height: 1.2;
    letter-spacing: -0.02em;
    position: relative;
    padding-bottom: var(--spacing-sm);
}

.hero-title::after {
    content: '';
    position: absolute;
    bottom: 0;
    left: 50%;
    transform: translateX(-50%);
    width: 80px;
    height: 3px;
    background: linear-gradient(90deg, 
        transparent 0%, 
        var(--primary-teal) 50%, 
        transparent 100%);
    opacity: 0.6;
}

.hero-subtitle {
    font-size: 1.25rem;
    color: var(--color-gray);
    margin-bottom: var(--spacing-lg);
    line-height: 1.8;
}

.hero-stats {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: var(--spacing-md);
    margin: var(--spacing-lg) 0;
}

.stat {
    padding: var(--spacing-md);
    background: var(--color-white);
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-md);
    transition: var(--transition-base);
}

.stat:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-lg);
}

.stat-number {
    font-size: 2.5rem;
    font-weight: 700;
    background: var(--gradient-primary);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    margin-bottom: var(--spacing-xs);
}

.stat-label {
    font-size: 0.875rem;
    color: var(--color-gray);
}

/* Hero Banner Style - Sophisticated Panels */
.hero-banner {
    background: linear-gradient(135deg, 
        rgba(30, 201, 164, 0.95) 0%, 
        rgba(74, 108, 247, 0.95) 50%, 
        rgba(147, 51, 234, 0.95) 100%);
    border: none;
    box-shadow: 0 4px 16px rgba(30, 201, 164, 0.15);
    padding: var(--spacing-lg) var(--spacing-xl);
    position: relative;
    overflow: hidden;
    display: flex;
    align-items: center;
    gap: var(--spacing-md);
    min-height: 4rem;
    transition: all 0.4s cubic-bezier(0.4, 0, 0.2, 1);
}

.hero-banner > i {
    font-size: 1.5rem;
    color: rgba(255, 255, 255, 0.9);
    flex-shrink: 0;
}

.hero-banner::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 2px;
    background: linear-gradient(90deg, 
        rgba(255, 255, 255, 0.3) 0%, 
        rgba(255, 255, 255, 0.7) 50%, 
        rgba(255, 255, 255, 0.3) 100%);
}

.hero-banner:hover {
    transform: translateY(-4px);
    box-shadow: 0 8px 24px rgba(30, 201, 164, 0.25);
}

.hero-banner .stat-label {
    color: #FFFFFF;
    font-size: 1.05rem;
    font-weight: 600;
    line-height: 1.5;
}
    text-align: center;
    line-height: 1.4;
    text-shadow: 0 2px 4px rgba(0, 0, 0, 0.1);
}

/* Trust Bar */
/* Metrics Section */
.metrics-section {
    background: linear-gradient(135deg, rgba(30, 201, 164, 0.03) 0%, rgba(184, 160, 220, 0.03) 100%);
    padding: var(--spacing-xl) 0;
}

.metrics-grid {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: var(--spacing-md);
    margin-top: var(--spacing-lg);
}

.metric-card {
    background: var(--color-white);
    padding: var(--spacing-lg);
    border-radius: var(--radius-lg);
    text-align: center;
    box-shadow: var(--shadow-md);
    transition: var(--transition-base);
    border: 2px solid transparent;
}

.metric-card:hover {
    transform: translateY(-6px);
    box-shadow: var(--shadow-lg);
    border-color: var(--primary-teal);
}

.metric-icon {
    font-size: 3rem;
    margin-bottom: var(--spacing-sm);
    line-height: 1;
}

.metric-number {
    font-size: 3rem;
    font-weight: 700;
    background: var(--gradient-primary);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    margin-bottom: var(--spacing-xs);
    line-height: 1.1;
}

.metric-label {
    font-size: 0.95rem;
    color: var(--color-gray);
    line-height: 1.4;
    font-weight: 500;
}

.hero-cta {
    display: flex;
    gap: var(--spacing-sm);
    justify-content: center;
    margin: var(--spacing-lg) 0;
}

.hero-announcement {
    display: flex;
    align-items: center;
    justify-content: center;
    gap: var(--spacing-sm);
    padding: var(--spacing-sm) var(--spacing-md);
    background: rgba(236, 72, 153, 0.05);
    border: 1px solid var(--primary-pink);
    border-radius: var(--radius-md);
    margin-top: var(--spacing-lg);
    font-size: 0.95rem;
}

.hero-announcement i {
    color: var(--primary-pink);
}

.hero-announcement a {
    color: var(--primary-pink);
    font-weight: 600;
    text-decoration: underline;
}

.hero-scroll {
    position: absolute;
    bottom: var(--spacing-md);
    left: 50%;
    transform: translateX(-50%);
    animation: bounce 2s infinite;
}

.scroll-indicator {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: var(--spacing-xs);
    color: var(--color-gray);
    font-size: 0.875rem;
}

/* ========================================
   Section Headers
   ======================================== */

.section-header {
    text-align: center;
    max-width: 800px;
    margin: 0 auto var(--spacing-lg);
}

.section-label {
    display: inline-block;
    font-size: 0.75rem;
    font-weight: 700;
    text-transform: uppercase;
    letter-spacing: 0.15em;
    color: var(--primary-teal);
    margin-bottom: 0.75rem;
}

.section-title {
    font-size: 2.75rem;
    margin-bottom: var(--spacing-sm);
    line-height: 1.2;
}

.section-subtitle {
    font-size: 1.125rem;
    color: var(--color-gray);
}

/* ========================================
   Science Section
   ======================================== */

.science {
    background: var(--color-off-white);
}

.science-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: var(--spacing-md);
    margin-bottom: var(--spacing-lg);
}

.science-card {
    background: var(--color-white);
    padding: var(--spacing-md);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    transition: var(--transition-base);
}

.science-card:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-lg);
}

.science-card.featured {
    border: 2px solid var(--primary-teal);
    grid-column: span 1;
}

.science-icon {
    width: 64px;
    height: 64px;
    display: flex;
    align-items: center;
    justify-content: center;
    background: var(--gradient-primary);
    border-radius: var(--radius-md);
    color: var(--color-white);
    font-size: 1.75rem;
    margin-bottom: var(--spacing-sm);
}

.science-card h3 {
    font-size: 1.5rem;
    margin-bottom: var(--spacing-sm);
}

.science-card p {
    color: var(--color-gray);
    margin-bottom: var(--spacing-sm);
    line-height: 1.7;
}

.feature-list {
    margin: var(--spacing-md) 0;
}

.feature-item {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
    padding: var(--spacing-xs) 0;
    color: var(--color-gray);
}

.feature-item i {
    color: var(--primary-teal);
    font-size: 1.25rem;
}

.advantage-list {
    margin-top: var(--spacing-sm);
}

.advantage-list li {
    display: flex;
    align-items: center;
    gap: var(--spacing-xs);
    padding: var(--spacing-xs) 0;
    color: var(--color-gray);
}

.advantage-list i {
    color: var(--primary-teal);
}

.mechanism-section {
    margin-top: var(--spacing-lg);
    padding: var(--spacing-lg);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
}

.mechanism-title {
    font-size: 2rem;
    text-align: center;
    margin-bottom: var(--spacing-md);
}

.mechanism-content {
    display: grid;
    grid-template-columns: 2fr 1fr;
    gap: var(--spacing-md);
    align-items: start;
}

.mechanism-text ul {
    margin-top: var(--spacing-sm);
}

.mechanism-text li {
    padding: var(--spacing-xs) 0;
    padding-left: var(--spacing-sm);
    color: var(--color-gray);
    line-height: 1.7;
}

.highlight-box {
    padding: var(--spacing-md);
    background: var(--gradient-hero);
    border-left: 4px solid var(--primary-teal);
    border-radius: var(--radius-md);
}

.highlight-box i {
    font-size: 2rem;
    color: var(--primary-teal);
    margin-bottom: var(--spacing-sm);
}

.highlight-box h4 {
    font-size: 1.25rem;
    margin-bottom: var(--spacing-sm);
}

.highlight-box p {
    color: var(--color-gray);
    line-height: 1.7;
}

/* How It Works Section */
.how-it-works-section {
    margin-top: var(--spacing-xl);
    padding: var(--spacing-lg);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-lg);
    border: 2px solid transparent;
    background-image: linear-gradient(white, white), var(--gradient-primary);
    background-origin: border-box;
    background-clip: padding-box, border-box;
}

.how-it-works-title {
    font-size: 2rem;
    text-align: center;
    margin-bottom: var(--spacing-xs);
    background: var(--gradient-primary);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}

.how-it-works-intro {
    text-align: center;
    color: var(--color-gray);
    font-size: 1.125rem;
    margin-bottom: var(--spacing-lg);
    max-width: 700px;
    margin-left: auto;
    margin-right: auto;
}

.mechanism-graphic {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-lg);
}

.mechanism-image {
    width: 100%;
    height: auto;
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-md);
    transition: var(--transition-base);
}

.mechanism-image:hover {
    transform: scale(1.02);
    box-shadow: var(--shadow-xl);
}

.mechanism-steps {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: var(--spacing-md);
}

.mechanism-step {
    padding: var(--spacing-md);
    background: var(--gradient-hero);
    border-radius: var(--radius-md);
    text-align: center;
    transition: var(--transition-base);
    position: relative;
}

.mechanism-step:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-md);
}

.mechanism-step::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 4px;
    background: var(--gradient-primary);
    border-radius: var(--radius-md) var(--radius-md) 0 0;
}

.step-number {
    width: 48px;
    height: 48px;
    margin: 0 auto var(--spacing-sm);
    display: flex;
    align-items: center;
    justify-content: center;
    background: var(--gradient-primary);
    border-radius: 50%;
    color: var(--color-white);
    font-size: 1.5rem;
    font-weight: 700;
    box-shadow: var(--shadow-md);
}

.mechanism-step h4 {
    font-size: 1.125rem;
    margin-bottom: var(--spacing-xs);
    color: var(--color-dark);
}

.mechanism-step p {
    font-size: 0.95rem;
    color: var(--color-gray);
    line-height: 1.6;
}

/* Comparison Section - One Drug vs Two Drugs */
.comparison-section {
    margin-top: var(--spacing-xl);
    padding: var(--spacing-xl) var(--spacing-lg);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-xl);
    border: 3px solid transparent;
    background-image: linear-gradient(white, white), var(--gradient-primary);
    background-origin: border-box;
    background-clip: padding-box, border-box;
}

.comparison-title {
    font-size: 2rem;
    text-align: center;
    margin-bottom: var(--spacing-xs);
    color: var(--color-dark);
}

.comparison-subtitle {
    text-align: center;
    color: var(--color-gray);
    font-size: 1.125rem;
    margin-bottom: var(--spacing-lg);
    max-width: 800px;
    margin-left: auto;
    margin-right: auto;
}

.comparison-image-container {
    margin: var(--spacing-lg) 0;
    text-align: center;
}

.comparison-image {
    width: 100%;
    max-width: 1000px;
    height: auto;
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-lg);
    transition: var(--transition-base);
}

/* Comparison Section - Seamlessly Integrated Design */
.comparison-section {
    margin-top: var(--spacing-xl);
    padding: var(--spacing-lg);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-xl);
}

.comparison-wrapper {
    max-width: 1100px;
    margin: 0 auto;
}

.comparison-graphic-container {
    margin-bottom: calc(var(--spacing-md) * -1);
    text-align: center;
}

.comparison-graphic {
    width: 100%;
    max-width: 100%;
    height: auto;
    display: block;
    border-radius: var(--radius-md) var(--radius-md) 0 0;
}

.comparison-graphic {
    margin: var(--spacing-lg) 0;
    text-align: center;
}

.comparison-image {
    width: 100%;
    max-width: 1000px;
    height: auto;
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-md);
}

.comparison-details {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 0;
    background: var(--color-white);
    border-radius: 0 0 var(--radius-md) var(--radius-md);
    overflow: hidden;
    box-shadow: 0 4px 12px rgba(0, 0, 0, 0.08);
}

.detail-panel {
    padding: var(--spacing-lg);
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
}

.challenge-panel {
    background: linear-gradient(135deg, rgba(239, 68, 68, 0.03) 0%, rgba(239, 68, 68, 0.01) 100%);
    border-left: 4px solid #EF4444;
    box-sizing: border-box;
    overflow: hidden;
}

.solution-panel {
    background: linear-gradient(135deg, rgba(30, 201, 164, 0.03) 0%, rgba(30, 201, 164, 0.01) 100%);
    border-right: 4px solid var(--primary-teal);
    box-sizing: border-box;
    overflow: hidden;
}

.panel-header {
    display: flex;
    align-items: center;
    gap: var(--spacing-xs);
    margin-bottom: var(--spacing-sm);
    padding-bottom: var(--spacing-sm);
    border-bottom: 2px solid rgba(0, 0, 0, 0.05);
}

.challenge-panel .panel-header i {
    color: #EF4444;
    font-size: 1.25rem;
}

.solution-panel .panel-header i {
    color: var(--primary-teal);
    font-size: 1.25rem;
}

.panel-header h4 {
    font-size: 1.125rem;
    margin: 0;
    color: var(--color-dark);
    font-weight: 700;
}

.detail-list {
    list-style: none;
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
    margin: 0;
    padding: 0;
}

.detail-list li {
    display: flex;
    align-items: flex-start;
    gap: var(--spacing-xs);
    font-size: 0.95rem;
    line-height: 1.5;
    color: var(--color-gray);
    padding: var(--spacing-xs) 0;
}

.challenge-panel .detail-list li i {
    color: #EF4444;
    font-size: 0.875rem;
    margin-top: 0.25rem;
    flex-shrink: 0;
}

.solution-panel .detail-list li i {
    color: var(--primary-teal);
    font-size: 0.875rem;
    margin-top: 0.25rem;
    flex-shrink: 0;
}

/* ========================================
   Clinical Progress Section
   ======================================== */

.clinical-progress {
    background: var(--color-white);
}

.timeline {
    position: relative;
    max-width: 900px;
    margin: 0 auto var(--spacing-lg);
}

.timeline::before {
    content: '';
    position: absolute;
    left: 32px;
    top: 0;
    bottom: 0;
    width: 2px;
    background: linear-gradient(to bottom, var(--primary-green), var(--primary-purple));
}

.timeline-item {
    position: relative;
    padding-left: 80px;
    padding-bottom: var(--spacing-lg);
}

.timeline-marker {
    position: absolute;
    left: 0;
    width: 64px;
    height: 64px;
    background: var(--color-white);
    border: 4px solid var(--primary-teal);
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    color: var(--primary-teal);
    z-index: 1;
}

.timeline-item.completed .timeline-marker {
    background: var(--primary-teal);
    color: var(--color-white);
}

.timeline-item.active .timeline-marker {
    border-color: var(--primary-pink);
    color: var(--primary-pink);
    animation: pulse 2s infinite;
}

.timeline-item.upcoming .timeline-marker {
    border-color: var(--color-gray-light);
    color: var(--color-gray-light);
}

.timeline-content {
    background: var(--color-off-white);
    padding: var(--spacing-md);
    border-radius: var(--radius-md);
    box-shadow: var(--shadow-sm);
}

.timeline-date {
    display: inline-block;
    font-size: 0.875rem;
    font-weight: 600;
    color: var(--primary-teal);
    margin-bottom: var(--spacing-xs);
}

.timeline-content h3 {
    font-size: 1.5rem;
    margin-bottom: var(--spacing-sm);
}

.timeline-content p {
    color: var(--color-gray);
    margin-bottom: var(--spacing-sm);
}

.timeline-content ul {
    margin-top: var(--spacing-sm);
}

.timeline-content li {
    padding: var(--spacing-xs) 0;
    padding-left: var(--spacing-sm);
    color: var(--color-gray);
    position: relative;
}

.timeline-content li::before {
    content: '•';
    position: absolute;
    left: 0;
    color: var(--primary-teal);
}

.publication-link {
    margin-top: var(--spacing-sm);
}

.publication-link a {
    display: inline-flex;
    align-items: center;
    gap: var(--spacing-xs);
    padding: var(--spacing-xs) var(--spacing-sm);
    background: var(--primary-teal);
    color: var(--color-white);
    border-radius: var(--radius-sm);
    font-weight: 600;
    transition: var(--transition-base);
}

.publication-link a:hover {
    transform: translateY(-2px);
    box-shadow: var(--shadow-md);
}

.results-highlight {
    margin: var(--spacing-lg) 0;
}

.results-highlight h3 {
    font-size: 2rem;
    text-align: center;
    margin-bottom: var(--spacing-md);
}

.results-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: var(--spacing-md);
}

.result-card {
    background: var(--color-white);
    padding: var(--spacing-md);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    text-align: center;
    transition: var(--transition-base);
}

.result-card:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-lg);
}

.result-icon {
    width: 64px;
    height: 64px;
    margin: 0 auto var(--spacing-sm);
    display: flex;
    align-items: center;
    justify-content: center;
    background: var(--gradient-primary);
    border-radius: var(--radius-md);
    color: var(--color-white);
    font-size: 1.75rem;
}

.result-stat {
    font-size: 2.5rem;
    font-weight: 700;
    background: var(--gradient-primary);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    margin-bottom: var(--spacing-xs);
}

.result-label {
    font-size: 1rem;
    font-weight: 600;
    color: var(--color-dark);
    margin-bottom: var(--spacing-xs);
}

.result-card p {
    font-size: 0.875rem;
    color: var(--color-gray);
}

.partnership-banner {
    margin-top: var(--spacing-lg);
    padding: var(--spacing-lg);
    background: var(--gradient-hero);
    border-radius: var(--radius-lg);
    border: 2px solid var(--primary-teal);
}

.partnership-content {
    display: flex;
    gap: var(--spacing-md);
    align-items: center;
}

.partnership-logo {
    width: 80px;
    height: 80px;
    display: flex;
    align-items: center;
    justify-content: center;
    background: var(--gradient-primary);
    border-radius: var(--radius-md);
    color: var(--color-white);
    font-size: 2.5rem;
    flex-shrink: 0;
}

.partnership-text h4 {
    font-size: 1.5rem;
    margin-bottom: var(--spacing-xs);
}

.partnership-text p {
    color: var(--color-gray);
    line-height: 1.7;
}

/* ========================================
   Market Opportunity Section
   ======================================== */

.market-opportunity {
    background: var(--color-white);
    padding: var(--spacing-xl) 0;
}

.market-grid {
    display: grid;
    grid-template-columns: repeat(4, 1fr);
    gap: var(--spacing-md);
    margin-bottom: var(--spacing-lg);
}

.market-card {
    background: var(--color-white);
    border: 2px solid #E2E8F0;
    border-radius: var(--radius-lg);
    padding: var(--spacing-md);
    transition: var(--transition-base);
    display: flex;
    flex-direction: column;
    position: relative;
}

.market-card:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-lg);
    border-color: var(--primary-teal);
}

.market-icon {
    width: 56px;
    height: 56px;
    border-radius: var(--radius-md);
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 1.5rem;
    margin-bottom: var(--spacing-sm);
    color: var(--color-white);
}

.market-icon.hnscc {
    background: linear-gradient(135deg, var(--primary-teal), var(--primary-blue));
}

.market-icon.crc {
    background: linear-gradient(135deg, var(--primary-blue), var(--primary-purple));
}

.market-icon.pancreatic {
    background: linear-gradient(135deg, #EC4899, var(--primary-purple));
}

.market-icon.endometrial {
    background: linear-gradient(135deg, var(--primary-purple), #8B5CF6);
}

.market-icon.breast {
    background: linear-gradient(135deg, #EC4899, #F472B6);
}

.market-card h3 {
    font-size: 1.25rem;
    font-weight: 700;
    margin-bottom: var(--spacing-sm);
    color: var(--color-dark);
    line-height: 1.3;
}

.indication-subtext {
    font-size: 0.9rem;
    font-weight: 400;
    color: var(--color-gray);
}

.market-stat {
    background: var(--gradient-hero);
    border-radius: var(--radius-md);
    padding: var(--spacing-sm);
    text-align: center;
    margin: var(--spacing-sm) 0;
}

.stat-number {
    font-size: 2rem;
    font-weight: 700;
    background: var(--gradient-primary);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
    margin-bottom: 0.25rem;
}

.stat-label {
    font-size: 0.85rem;
    color: var(--color-gray);
    font-weight: 500;
}

.market-features {
    list-style: none;
    padding: 0;
    margin: var(--spacing-sm) 0 0 0;
    flex-grow: 1;
}

.market-features li {
    display: flex;
    align-items: flex-start;
    gap: 0.5rem;
    margin-bottom: 0.75rem;
    font-size: 0.9rem;
    color: var(--color-dark-alt);
    line-height: 1.5;
}

.market-features li i {
    color: var(--primary-teal);
    font-size: 0.85rem;
    margin-top: 0.2rem;
    flex-shrink: 0;
}

/* Partnership Opportunities */
.partnership-opportunities {
    background: linear-gradient(135deg, #F0F9FF 0%, #F3E8FF 100%);
    border: 2px solid var(--primary-teal);
    border-radius: var(--radius-lg);
    padding: var(--spacing-md);
    text-align: center;
}

.partnership-header {
    margin-bottom: var(--spacing-sm);
}

.partnership-header h3 {
    font-size: 1.25rem;
    font-weight: 700;
    color: var(--color-dark);
    margin-bottom: 0.5rem;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 0.75rem;
}

.partnership-header h3 i {
    color: var(--primary-teal);
}

.partnership-header p {
    font-size: 0.95rem;
    color: var(--color-gray);
    font-family: monospace;
    font-weight: 500;
}

.partnership-badges {
    display: flex;
    justify-content: center;
    gap: var(--spacing-sm);
    flex-wrap: wrap;
}

.partner-badge {
    display: inline-block;
    padding: 0.5rem 1.25rem;
    border-radius: 50px;
    font-weight: 600;
    font-size: 0.9rem;
    color: var(--color-dark);
    transition: var(--transition-fast);
    cursor: default;
}

.partner-badge.kras {
    background: #10B981;
    color: var(--color-white);
}

.partner-badge.cdk {
    background: #8B5CF6;
    color: var(--color-white);
}

.partner-badge.radiation {
    background: #F59E0B;
    color: var(--color-white);
}

.partner-badge:hover {
    transform: translateY(-2px);
    box-shadow: var(--shadow-md);
}

/* Responsive Design for Market Section */
@media (max-width: 1200px) {
    .market-grid {
        grid-template-columns: repeat(2, 1fr);
    }
}

@media (max-width: 768px) {
    .market-grid {
        grid-template-columns: 1fr;
    }
    
    .partnership-badges {
        flex-direction: column;
        align-items: center;
    }
}

/* ========================================
   Pipeline Section
   ======================================== */

.pipeline {
    background: var(--color-off-white);
}

.pipeline-table {
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    overflow: hidden;
    margin-bottom: var(--spacing-lg);
}

.pipeline-header {
    display: grid;
    grid-template-columns: 1.5fr 1fr 1.5fr 2fr;
    gap: var(--spacing-md);
    padding: var(--spacing-md);
    background: var(--gradient-primary);
    color: var(--color-white);
    font-weight: 600;
}

.pipeline-row {
    display: grid;
    grid-template-columns: 1.5fr 1fr 1.5fr 2fr;
    gap: var(--spacing-md);
    padding: var(--spacing-md);
    align-items: center;
}

.pipeline-row.featured {
    background: var(--gradient-hero);
}

.pipeline-row:not(.featured) {
    border-bottom: 1px solid var(--color-gray-light);
    transition: var(--transition-base);
}

.pipeline-row:not(.featured):hover {
    background: rgba(20, 184, 166, 0.05);
}

.candidate-name {
    font-size: 1.25rem;
    font-weight: 700;
    color: var(--color-dark);
}

.candidate-type {
    font-size: 0.75rem;
    color: var(--primary-teal);
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.05em;
}

.target-list {
    display: flex;
    gap: var(--spacing-xs);
    flex-wrap: wrap;
}

.target-badge {
    padding: 0.375rem 0.75rem;
    background: var(--primary-teal);
    color: var(--color-white);
    border-radius: var(--radius-sm);
    font-size: 0.875rem;
    font-weight: 600;
}

.indication-list {
    font-size: 0.95rem;
}

.indication-list li {
    padding: 0.25rem 0;
    color: var(--color-gray);
}

.stage-progress {
    display: flex;
    gap: var(--spacing-sm);
    align-items: center;
}

.stage-item {
    display: flex;
    flex-direction: column;
    align-items: center;
    gap: 0.25rem;
    font-size: 0.75rem;
}

.stage-item.completed {
    color: var(--primary-teal);
}

.stage-item.active {
    color: var(--primary-pink);
}

.stage-item i {
    font-size: 1.5rem;
}

.pipeline-focus {
    padding: var(--spacing-lg);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    text-align: center;
}

.pipeline-focus h3 {
    font-size: 1.75rem;
    margin-bottom: var(--spacing-sm);
}

.pipeline-focus p {
    color: var(--color-gray);
    line-height: 1.8;
    max-width: 800px;
    margin: 0 auto;
}

/* ========================================
   News Section
   ======================================== */

.news {
    background: var(--color-white);
}

.news-grid {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(350px, 1fr));
    gap: var(--spacing-md);
}

.news-card {
    background: var(--color-off-white);
    border-radius: var(--radius-lg);
    overflow: hidden;
    box-shadow: var(--shadow-md);
    transition: var(--transition-base);
}

.news-card:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-lg);
}

.news-card.featured {
    grid-column: span 2;
}

.news-image {
    position: relative;
    height: 200px;
    background: var(--gradient-primary);
    display: flex;
    align-items: flex-start;
    justify-content: space-between;
    padding: var(--spacing-sm);
}

.news-category {
    padding: 0.375rem 0.75rem;
    background: var(--color-white);
    color: var(--primary-teal);
    border-radius: var(--radius-sm);
    font-size: 0.75rem;
    font-weight: 600;
    text-transform: uppercase;
}

.news-date {
    padding: 0.375rem 0.75rem;
    background: rgba(255, 255, 255, 0.9);
    color: var(--color-dark);
    border-radius: var(--radius-sm);
    font-size: 0.875rem;
    font-weight: 600;
}

.news-content {
    padding: var(--spacing-md);
}

.news-content h3 {
    font-size: 1.25rem;
    margin-bottom: var(--spacing-sm);
    line-height: 1.4;
}

.news-content p {
    color: var(--color-gray);
    margin-bottom: var(--spacing-sm);
    line-height: 1.7;
}

.news-highlights {
    display: flex;
    flex-wrap: wrap;
    gap: var(--spacing-xs);
    margin: var(--spacing-sm) 0;
}

.news-highlights span {
    display: inline-flex;
    align-items: center;
    gap: 0.25rem;
    padding: 0.25rem 0.75rem;
    background: rgba(20, 184, 166, 0.1);
    color: var(--primary-teal);
    border-radius: var(--radius-sm);
    font-size: 0.875rem;
}

.news-link {
    display: inline-flex;
    align-items: center;
    gap: var(--spacing-xs);
    color: var(--primary-teal);
    font-weight: 600;
    margin-top: var(--spacing-sm);
}

.news-link:hover {
    gap: calc(var(--spacing-xs) + 0.25rem);
}

/* ========================================
   About Section
   ======================================== */

.about {
    background: var(--color-off-white);
}

.about-content {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-lg);
}

.about-story {
    padding: var(--spacing-lg);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
}

.about-story h3 {
    font-size: 2rem;
    margin-bottom: var(--spacing-sm);
}

.about-story p {
    color: var(--color-gray);
    line-height: 1.8;
    margin-bottom: var(--spacing-sm);
}

.leadership-section {
    padding: var(--spacing-lg);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
}

.leadership-section h3 {
    font-size: 2rem;
    margin-bottom: var(--spacing-md);
    text-align: center;
}

.leadership-grid {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: var(--spacing-md);
}

.leader-card {
    padding: var(--spacing-md);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    transition: var(--transition-base);
}

.leader-card:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-lg);
}

.leader-photo {
    display: flex;
    justify-content: center;
    margin-bottom: var(--spacing-md);
}

.photo-placeholder {
    width: 120px;
    height: 120px;
    border-radius: 50%;
    display: flex;
    align-items: center;
    justify-content: center;
    border: 4px solid transparent;
    background-image: 
        linear-gradient(white, white),
        var(--gradient-primary);
    background-origin: border-box;
    background-clip: padding-box, border-box;
    position: relative;
    overflow: hidden;
}

.photo-placeholder i {
    font-size: 3rem;
    color: #999;
    position: relative;
    z-index: 2;
}

.leader-image {
    width: 100%;
    height: 100%;
    object-fit: cover;
    border-radius: 50%;
    position: relative;
    z-index: 3;
}

.leader-info h4 {
    font-size: 1.25rem;
    margin-bottom: 0.25rem;
}

.leader-title {
    font-size: 0.95rem;
    color: var(--primary-teal);
    font-weight: 600;
    margin-bottom: var(--spacing-sm);
}

.leader-bio {
    color: var(--color-gray);
    line-height: 1.7;
}

.advisory-board {
    padding: var(--spacing-lg);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
}

.advisory-board h3 {
    font-size: 2rem;
    margin-bottom: var(--spacing-md);
    text-align: center;
}

.advisor-card {
    padding: var(--spacing-md);
    background: var(--gradient-hero);
    border-left: 4px solid var(--primary-pink);
    border-radius: var(--radius-md);
}

.advisor-info h4 {
    font-size: 1.25rem;
    margin-bottom: 0.25rem;
}

.advisor-title {
    font-size: 0.95rem;
    color: var(--primary-pink);
    font-weight: 600;
    margin-bottom: var(--spacing-sm);
    line-height: 1.6;
}

.advisor-bio {
    color: var(--color-gray);
    line-height: 1.7;
}

.partnerships {
    padding: var(--spacing-lg);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
}

.partnerships h3 {
    font-size: 2rem;
    margin-bottom: var(--spacing-md);
    text-align: center;
}

.partner-list {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-md);
}

.partner-item {
    display: flex;
    gap: var(--spacing-md);
    padding: var(--spacing-md);
    background: var(--color-off-white);
    border-radius: var(--radius-md);
}

.partner-icon {
    width: 64px;
    height: 64px;
    display: flex;
    align-items: center;
    justify-content: center;
    background: var(--gradient-primary);
    border-radius: var(--radius-md);
    color: var(--color-white);
    font-size: 1.75rem;
    flex-shrink: 0;
}

.partner-details h4 {
    font-size: 1.125rem;
    margin-bottom: 0.25rem;
}

.partner-details p {
    color: var(--color-gray);
}

.mission-vision {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(300px, 1fr));
    gap: var(--spacing-md);
}

.mission, .vision {
    padding: var(--spacing-lg);
    background: var(--color-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
}

.mission h3, .vision h3 {
    display: flex;
    align-items: center;
    gap: var(--spacing-xs);
    font-size: 1.5rem;
    margin-bottom: var(--spacing-sm);
}

.mission h3 i {
    color: var(--primary-teal);
}

.vision h3 i {
    color: var(--primary-pink);
}

.mission p, .vision p {
    color: var(--color-gray);
    line-height: 1.8;
}

/* ========================================
   Contact Section
   ======================================== */

.contact {
    background: var(--color-white);
}

.contact-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
    gap: var(--spacing-md);
    margin-bottom: var(--spacing-lg);
    max-width: 600px;
    margin-left: auto;
    margin-right: auto;
}

.contact-card {
    padding: var(--spacing-md);
    background: var(--color-off-white);
    border-radius: var(--radius-lg);
    box-shadow: var(--shadow-md);
    text-align: center;
    transition: var(--transition-base);
}

.contact-card:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-lg);
}

.contact-icon {
    width: 64px;
    height: 64px;
    margin: 0 auto var(--spacing-sm);
    display: flex;
    align-items: center;
    justify-content: center;
    background: var(--gradient-primary);
    border-radius: var(--radius-md);
    color: var(--color-white);
    font-size: 1.75rem;
}

.contact-card h3 {
    font-size: 1.25rem;
    margin-bottom: var(--spacing-xs);
}

.contact-card p {
    color: var(--color-gray);
    margin-bottom: var(--spacing-sm);
    font-size: 0.95rem;
}

.contact-link {
    display: inline-block;
    color: var(--primary-teal);
    font-weight: 600;
    padding: var(--spacing-xs) var(--spacing-sm);
    background: rgba(20, 184, 166, 0.1);
    border-radius: var(--radius-sm);
    transition: var(--transition-base);
}

.contact-link:hover {
    background: var(--primary-teal);
    color: var(--color-white);
}

.contact-info {
    display: flex;
    justify-content: center;
    gap: var(--spacing-lg);
    padding: var(--spacing-md);
    background: var(--color-off-white);
    border-radius: var(--radius-lg);
}

.info-group {
    display: flex;
    align-items: center;
    gap: var(--spacing-sm);
}

.info-group i {
    color: var(--primary-teal);
    font-size: 1.25rem;
}

.info-group strong {
    display: block;
    margin-bottom: 0.25rem;
}

.info-group p, .info-group a {
    color: var(--color-gray);
}

.info-group a:hover {
    color: var(--primary-teal);
}

/* ========================================
   Footer
   ======================================== */

.footer {
    background: var(--color-dark);
    color: var(--color-white);
    padding: var(--spacing-lg) 0 var(--spacing-md);
}

.footer-content {
    display: grid;
    grid-template-columns: 1.5fr 2fr;
    gap: var(--spacing-lg);
    margin-bottom: var(--spacing-lg);
}

.footer-brand {
    display: flex;
    flex-direction: column;
    gap: var(--spacing-sm);
}

.footer-logo .logo-text {
    font-size: 1.75rem;
    color: var(--color-white);
}

.footer-tagline {
    color: var(--color-gray-light);
    font-size: 0.95rem;
}

.footer-links {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: var(--spacing-md);
}

.footer-column h4 {
    color: var(--color-white);
    font-size: 1rem;
    margin-bottom: var(--spacing-sm);
}

.footer-column ul li {
    margin-bottom: var(--spacing-xs);
}

.footer-column a {
    color: var(--color-gray-light);
    font-size: 0.95rem;
}

.footer-column a:hover {
    color: var(--primary-teal);
}

.footer-bottom {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding-top: var(--spacing-md);
    border-top: 1px solid rgba(255, 255, 255, 0.1);
}

.footer-bottom p {
    color: var(--color-gray-light);
    font-size: 0.875rem;
}

.footer-legal {
    display: flex;
    gap: var(--spacing-md);
}

.footer-legal a {
    color: var(--color-gray-light);
    font-size: 0.875rem;
}

.footer-legal a:hover {
    color: var(--primary-teal);
}

/* ========================================
   Page Hero (for sub-pages)
   ======================================== */

.page-hero {
    background: linear-gradient(135deg, rgba(30, 201, 164, 0.1) 0%, rgba(184, 160, 220, 0.1) 100%);
    padding: 8rem 0 4rem;
    text-align: center;
}

.page-hero h1 {
    font-size: 3.5rem;
    margin: 1rem 0;
    background: var(--gradient-primary);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    background-clip: text;
}

.page-hero .lead {
    font-size: 1.25rem;
    color: var(--color-gray);
    max-width: 700px;
    margin: 0 auto;
}

/* ========================================
   Animations
   ======================================== */

@keyframes fadeInUp {
    from {
        opacity: 0;
        transform: translateY(30px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

@keyframes bounce {
    0%, 100% {
        transform: translateX(-50%) translateY(0);
    }
    50% {
        transform: translateX(-50%) translateY(-10px);
    }
}

@keyframes pulse {
    0%, 100% {
        opacity: 1;
    }
    50% {
        opacity: 0.5;
    }
}

/* ========================================
   Responsive Design
   ======================================== */

@media (max-width: 1200px) {
    .nav-menu {
        gap: 1rem;
    }
    
    .nav-link {
        font-size: 0.85rem;
        padding: var(--spacing-xs) 0.5rem;
    }
}

@media (max-width: 1024px) {
    .hero-title {
        font-size: 3rem;
    }
    
    .section-title {
        font-size: 2.5rem;
    }
    
    .mechanism-content {
        grid-template-columns: 1fr;
    }
    
    .mechanism-steps {
        grid-template-columns: 1fr;
    }
    
    .comparison-details {
        grid-template-columns: 1fr;
    }
    
    .comparison-title {
        font-size: 1.75rem;
    }
    
    .detail-panel {
        padding: var(--spacing-md);
    }
    
    .solution-panel {
        border-right: none;
        border-left: 4px solid var(--primary-teal);
        border-top: 2px solid rgba(30, 201, 164, 0.2);
    }
    
    .challenge-panel {
        border-bottom: 2px solid rgba(239, 68, 68, 0.2);
    }
    
    
    .metrics-grid {
        grid-template-columns: repeat(2, 1fr);
    }
    
    .news-card.featured {
        grid-column: span 1;
    }
    
    .leadership-grid {
        grid-template-columns: 1fr;
    }
    
    .nav-menu {
        gap: 0.8rem;
    }
    
    .nav-link {
        font-size: 0.8rem;
        padding: var(--spacing-xs) 0.4rem;
    }
}

@media (max-width: 768px) {
    .mobile-toggle {
        display: flex;
    }
    
    .logo-mark {
        height: 32px;
    }
    
    .logo-text {
        font-size: 1.25rem;
    }
    
    .nav-menu {
        position: absolute;
        top: 100%;
        left: 0;
        right: 0;
        background: var(--color-white);
        flex-direction: column;
        padding: var(--spacing-md);
        box-shadow: var(--shadow-lg);
        transform: translateY(-100%);
        opacity: 0;
        pointer-events: none;
        transition: var(--transition-base);
    }
    
    .nav-menu.active {
        transform: translateY(0);
        opacity: 1;
        pointer-events: all;
    }
    
    .container {
        padding: 0 var(--spacing-sm);
        max-width: 100%;
        overflow-x: hidden;
    }
    
    .hero-title {
        font-size: 2.5rem;
    }
    
    .hero-subtitle {
        font-size: 1rem;
    }
    
    .hero-badge {
        font-size: 0.8rem;
        padding: 0.5rem 1rem;
        margin-bottom: 1rem;
    }
    
    .section-label {
        font-size: 0.7rem;
        margin-bottom: 0.5rem;
    }
    
    .section-title {
        font-size: 2rem;
    }
    
    .hero-stats {
        grid-template-columns: 1fr;
    }
    
    .hero-cta {
        flex-direction: column;
    }
    
    
    .metrics-grid {
        grid-template-columns: 1fr;
    }
    
    .section-title {
        font-size: 2rem;
    }
    
    .comparison-title {
        font-size: 1.5rem;
        padding: 0 var(--spacing-sm);
        word-wrap: break-word;
        overflow-wrap: break-word;
    }
    
    .comparison-section {
        padding: var(--spacing-md) var(--spacing-sm);
        margin-left: 0;
        margin-right: 0;
        overflow: hidden;
    }
    
    .comparison-graphic {
        margin: var(--spacing-md) 0;
        overflow: hidden;
    }
    
    .comparison-image {
        width: 100%;
        height: auto;
        max-width: 100%;
        display: block;
    }
    
    .comparison-details {
        width: 100%;
        overflow: hidden;
    }
    
    .detail-panel {
        padding: var(--spacing-sm) var(--spacing-sm);
        width: 100%;
        overflow: hidden;
    }
    
    .panel-header {
        flex-wrap: wrap;
    }
    
    .panel-header h4 {
        font-size: 1rem;
        word-wrap: break-word;
        overflow-wrap: break-word;
    }
    
    .detail-list {
        width: 100%;
    }
    
    .detail-list li {
        font-size: 0.9rem;
        word-wrap: break-word;
        overflow-wrap: break-word;
        width: 100%;
    }
    
    .detail-list li span {
        word-wrap: break-word;
        overflow-wrap: break-word;
    }
    
    .science-grid {
        grid-template-columns: 1fr;
    }
    
    .mechanism-steps {
        grid-template-columns: 1fr;
    }
    
    .comparison-details {
        grid-template-columns: 1fr;
    }
    
    .solution-panel {
        border-right: none;
        border-left: 4px solid var(--primary-teal);
    }
    
    .timeline::before {
        left: 16px;
    }
    
    .timeline-item {
        padding-left: 60px;
    }
    
    .timeline-marker {
        width: 48px;
        height: 48px;
        font-size: 1.25rem;
    }
    
    .results-grid {
        grid-template-columns: 1fr;
    }
    
    .pipeline-header,
    .pipeline-row {
        grid-template-columns: 1fr;
        gap: var(--spacing-sm);
    }
    
    .pipeline-header {
        display: none;
    }
    
    .stage-progress {
        flex-direction: column;
        align-items: flex-start;
    }
    
    .news-grid {
        grid-template-columns: 1fr;
    }
    
    .footer-content {
        grid-template-columns: 1fr;
    }
    
    .footer-links {
        grid-template-columns: 1fr;
    }
    
    .footer-bottom {
        flex-direction: column;
        gap: var(--spacing-sm);
        text-align: center;
    }
    
    .partnership-content {
        flex-direction: column;
        text-align: center;
    }
    
    .contact-info {
        flex-direction: column;
        gap: var(--spacing-md);
    }
}

@media (max-width: 480px) {
    :root {
        --spacing-lg: 3rem;
        --spacing-xl: 4rem;
        --spacing-md: 1.5rem;
        --spacing-sm: 0.75rem;
    }
    
    * {
        box-sizing: border-box;
    }
    
    body {
        width: 100%;
        overflow-x: hidden;
    }
    
    .container {
        padding: 0 var(--spacing-sm);
        width: 100%;
        max-width: 100%;
    }
    
    .logo-mark {
        height: 28px;
    }
    
    .logo-text {
        font-size: 1.1rem;
    }
    
    .hero-title {
        font-size: 2rem;
        word-wrap: break-word;
    }
    
    .stat-number {
        font-size: 2rem;
    }
    
    .hero-announcement {
        flex-direction: column;
        text-align: center;
    }
    
    .comparison-title {
        font-size: 1.25rem;
        line-height: 1.3;
    }
    
    .comparison-section {
        padding: var(--spacing-sm);
        border-radius: var(--radius-md);
    }
    
    .detail-panel {
        padding: var(--spacing-sm);
    }
    
    .panel-header h4 {
        font-size: 0.95rem;
    }
    
    .detail-list li {
        font-size: 0.85rem;
        gap: 0.375rem;
    }
}